Rapid Screening for C3435t Polymorphism in Exon 26 of the Multi-Drug Resistance (MDR1) Gene in Malay Patients with Acute Leukemia

Yahaya, Badrul Hisham (2005) Rapid Screening for C3435t Polymorphism in Exon 26 of the Multi-Drug Resistance (MDR1) Gene in Malay Patients with Acute Leukemia. The Malaysian Journal of Medical Sciences, 12 (1). p. 61. ISSN 1394-195X

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Abstract

The over expression of P-glycoprotein has been found to be associated with therapy resistance in hematological malignancies including acute leukemias. Recently, a single nucleotide polymorphism (SNP) in exon 26 (C3435T) in the MDR1 gene has shown to have functional consequences with altered expression of P-gp. Denaturing HPLC has been established as a rapid method for screening SNP in the form of heteroduplex of the DNA samples under partially denaturing condition.

Item Type:	Article
Subjects:	R Medicine > R Medicine (General) > R5-920 Medicine (General)
Divisions:	Kampus Kesihatan (Health Campus) > Pusat Pengajian Sains Perubatan (School of Medical Sciences) > Article Zoom Profil Pakar (Expert Profile) > Badrul Hisham Yahaya (Advanced Medical & Dental Institute) Penerbit Universiti Sains Malaysia (USM Press) > The Malaysian Journal of Medical Sciences
Depositing User:	Mr Firdaus Mohamad
Date Deposited:	11 Aug 2015 03:44
Last Modified:	01 Sep 2017 10:46
URI:	http://eprints.usm.my/id/eprint/29260

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