Karim , Sabiha
(2011)
Design And Evaluation Of
Mul Tip Articulate. Systems Prepared Using
Sieving-Spheronisation And Extrusionspheronisation.
PhD thesis, Universiti Sains Malaysia.
Abstract
Pelletised dosage forms can be prepared by different methods which, in general,
are time consuming and labor intensive. The current study was carried out to assess the
feasibility of preparing spherical pellets by sieving the wet powder mass followed by
spheronisation. This method was compared with extrusion-spheronisation process in
terms of physical characteristics and in-vitro dissolution profile of the developed
fommlations.
Dosej berbentuk pelet boleh disediakan melalui pelbagai kaedah yang biasanya
memakan masa serta memerlukan tenaga kerja yang banyak. Kajian ini dijalankan untuk
menilai kebolehlaksanaan penyediaan pelet bulat melalui tapisan jisim serbuk basah dan
dikuti dengan proses sferonisasi. Kaedah ini dibandingkan dengan proses sferonisasi
ekstrusi dari segi ciri-ciri fizikal and profil pelarutan in-vitro daripada rumusan yang
dibangunkan.
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