Genotoxic Evaluation Of Synthetic Hdroxyapatite Using Mammalian Bone Marrow Chromosome Aberration Test.

Abstract

Some of the beneficial biocompatible properties of hydroxyapatite [Ca10(PO4)6(OH)2],the major component and an essential ingredient of normal bone and teeth are that iti is rapidly integrated into the human body and will bond to bone forming indistingushable unions. But, before new materials are approved for medical use, mutagenesis system to exclude cytotoxic, mutagenic or carcinogenic properties are applied worldwide. This study aims to detect any chromosomal aberrations induced by the synthetic hydroxyapatite granules[Manufactured by USM,Penang] int he bone marrow cells of mice. the mitotic indices of the groups treated with synthetic hydroxyapatite granules and distilled water.